HORDB

ID: hor001594
Uniprot ID: Q07981
Protein name: ENNNGYIRF-amide
Gene name: NA
Organism: Cornu aspersum (Brown garden snail) (Helix aspersa)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: Central nervous system.
Disease: NA
Comments: NA
Taxonomy: Cornu (subgenus), Cornu (genus), Helicidae (family), Helicoidea (superfamily), Helicina, Stylommatophora (order), Eupulmonata (superorder), Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: ENNNGYIRF
Length: 9(39-47)
Propeptide: MTSLCLTIAPAVLSLICLSSYGWAEGDTTDNEYLRFGRENNNGYIRFGRNDPFLRFGKKSDPFLRFGKQDPFLRIGRQDPFLRFGKQDPFLRFGKQDPFLRIGKQDPFLRFGRSEPYLRFGRNDPYLRFGRNDPYLRFGRNDPYLRFGRNDPYLRFGKNDPFLRFGKSVDGEIEAGVDAVTLSREHEFAHENAASDRQKRSAYTDAIDKDNSLTSLVREAREASDSNGQINDGKVVEVPVFRDTRNGHYMRFGKK
Signal peptide: MTSLCLTIAPAVLSLICLS
Modification: T9 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Can function as both cardioregulatory hormones and transmitters and may regulate cardiovascular function.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001594_AF2.pdb

hor001594_ESM.pdb

Mass:	126906	Formula:	C49H71N15O16
Absent amino acids:	ACDHKLMPQSTVW	Common amino acids:	N
pI:	6.4	Basic residues:	1
Polar residues:	5	Hydrophobic residues:	2
Hydrophobicity:	-143.33	Boman Index:	-3295
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	43.33
Instability Index:	-1724.44	Extinction Coefficient cystines:	1490
Absorbance 280nm:	186.25